Billboard Year-End Hot 100 singles of 2010
- "Tik Tok" Kesha
- "Need You Now" Lady Antebellum
- "Hey, Soul Sister" Train
- "California Gurls" Katy Perry featuring Snoop Dogg
- "OMG" Usher featuring will.i.am
- "Airplanes" B.o.B featuring Hayley Williams
- "Love the Way You Lie" Eminem featuring Rihanna
- "Bad Romance" Lady Gaga
- "Dynamite" Taio Cruz
- "Break Your Heart" Taio Cruz featuring Ludacris
- "Nothin' on You" B.o.B featuring Bruno Mars
- "I Like It" Enrique Iglesias featuring Pitbull
- "BedRock" Young Money featuring Lloyd
- "In My Head" Jason Derulo
- "Rude Boy" Rihanna
- "Telephone" Lady Gaga featuring Beyoncé
- "Teenage Dream" Katy Perry
- "Just the Way You Are" Bruno Mars
- "Cooler Than Me" Mike Posner
- "Imma Be" The Black Eyed Peas
- "Empire State of Mind" Jay-Z featuring Alicia Keys
- "DJ Got Us Fallin' in Love" Usher featuring Pitbull
- "Billionaire" Travie McCoy featuring Bruno Mars
- "Not Afraid" Eminem
- "Replay" Iyaz
- "Sexy Bitch" David Guetta featuring Akon
- "Breakeven" The Script
- "Your Love Is My Drug" Kesha
- "I Gotta Feeling" The Black Eyed Peas
- "Fireflies" Owl City
- "Say Aah" Trey Songz featuring Fabolous
- "Find Your Love" Drake
- "Alejandro" Lady Gaga
- "Ridin' Solo" Jason Derulo
- "Just a Dream" Nelly
- "How Low" Ludacris
- "Like a G6" Far East Movement featuring The Cataracs and Dev
- "Carry Out" Timbaland featuring Justin Timberlake
- "Haven't Met You Yet" Michael Bublé
- "Club Can't Handle Me" Flo Rida featuring David Guetta
- "Down" Jay Sean featuring Lil Wayne
- "Bulletproof" La Roux
- "Whatcha Say" Jason Derulo
- "Baby" Justin Bieber featuring Ludacris
- "Whataya Want from Me" Adam Lambert
- "Mine" Taylor Swift
- "Only Girl (In the World)" Rihanna
- "Live Like We're Dying" Kris Allen
- "Hard" Rihanna featuring Jeezy
- "Young Forever" Jay-Z featuring Mr Hudson
- "Blah Blah Blah" Kesha featuring 3OH!3
- "Bottoms Up" Trey Songz featuring Nicki Minaj
- "Do You Remember" Jay Sean featuring Sean Paul and Lil Jon
- "All the Right Moves" OneRepublic
- "According to You" Orianthi
- "My Chick Bad" Ludacris featuring Nicki Minaj
- "You Belong with Me" Taylor Swift
- "Meet Me Halfway" The Black Eyed Peas
- "Take It Off" Kesha
- "Over" Drake
- "Animal" Neon Trees
- "Misery" Maroon 5
- "Magic" B.o.B featuring Rivers Cuomo
- "Paparazzi" Lady Gaga
- "Tie Me Down" New Boyz featuring Ray J
- "Your Love" Nicki Minaj
- "Party in the U.S.A." Miley Cyrus
- "Deuces" Chris Brown featuring Tyga and Kevin McCall
- "3" Britney Spears
- "Impossible" Shontelle
- "Forever" Drake featuring Kanye West, Lil Wayne and Eminem
- "Two Is Better Than One" Boys Like Girls featuring Taylor Swift
- "My First Kiss" 3OH!3 featuring Kesha
- "Already Gone" Kelly Clarkson
- "Rock That Body" The Black Eyed Peas
- "Secrets" OneRepublic
- "Naturally" Selena Gomez & the Scene
- "Un-Thinkable (I'm Ready)" Alicia Keys
- "All I Do Is Win" DJ Khaled featuring T-Pain, Ludacris, Snoop Dogg and Rick Ross
- "I Made It (Cash Money Heroes)" Kevin Rudolf featuring Birdman, Jay Sean and Lil Wayne
- "Stuck Like Glue" Sugarland
- "Hey Daddy (Daddy's Home)" Usher featuring Plies
- "There Goes My Baby" Usher
- "Today Was a Fairytale" Taylor Swift
- "Say Something" Timbaland featuring Drake
- "Sweet Dreams" Beyoncé
- "Use Somebody" Kings of Leon
- "Undo It" Carrie Underwood
- "Eenie Meenie" Sean Kingston and Justin Bieber
- "Right Above It" Lil Wayne featuring Drake
- "The House That Built Me" Miranda Lambert
- "If I Die Young" The Band Perry
- "The Only Exception" Paramore
- "American Honey" Lady Antebellum
- "King of Anything" Sara Bareilles
- "Life After You" Daughtry
- "Smile" Uncle Kracker
- "Teach Me How to Dougie" Cali Swag District
- "Try Sleeping with a Broken Heart" Alicia Keys
- "Lover, Lover" Jerrod Niemann